There is nothing wrong with this technique IF you start off with that setup.
But if you have multiple sites and you ve ALLREADY developed your sites using multiple databases and you want them REUNITED in one database. You should be aware of the following issue:
Drupal 5 uses the sequences table to keep track of autoincrement of node ids user ids, etc...
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The blog contains tips for using the Drupal content management system/framework.
Dominique De Cooman is a drupal developer consultant working in Antwerp and Living in Gent. Feel free to contact me to hire me for your projects